Cagri
Research description
Cagri (AM-833; CAS 1393461-38-5) is a synthetic, lipidated long-acting analogue of the pancreatic peptide hormone amylin, engineered for sustained activity at all three amylin receptor subtypes (AMY1R, AMY2R, AMY3R) and the calcitonin receptor (CTR) — classifying it as a dual amylin and calcitonin receptor agonist (DACRA).
A C20 fatty diacid N-terminal lipidation strategy enables albumin binding, reducing plasma clearance and extending circulating half-life to approximately 159–195 hours (~7 days) in pharmacokinetic research studies. Targeted structural modifications (14E/17R salt-bridge substitutions; 25P/28P/29P proline substitutions) simultaneously prevent amyloid fibril formation. Cryo-EM structures published in Nature Communications (2025) resolve Cagri bound to Gs-coupled active AMY1R, AMY2R, AMY3R, and CTR at atomic resolution.
Preclinical research in RAMP1/3 knockout mouse models confirms that Cagri's metabolic signalling effects are specifically dependent on intact AMY1R and AMY3R function in hindbrain neuronal circuits (area postrema/NTS).
FOR RESEARCH USE ONLY. Not for consumption, human or animal administration, or any application outside a controlled non-clinical laboratory setting.
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Research use only
For laboratory research use only. Not for human or veterinary use. Not a drug, supplement, food, or cosmetic. Product descriptions summarise published laboratory literature and are not a recommendation for any use in humans or animals.
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Reconstitution figures for any fill weight and diluent volume can be worked out on the concentration calculator. Solubility and storage data on this page describe laboratory handling of the material only.
This compound is not light-sensitive under normal laboratory lighting. Standard clear containers are acceptable for reconstituted stock.
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